Strategies to tackle SARS-CoV-2 Mu, a newly classified variant of interest likely to resist currently available COVID-19 vaccines현재 사용 가능한 COVID-19 백신에 저항할 가능성이 있는 새로 분류된 관심 변종인 SARS-CoV-2 Mu에 대처하기 위한 전략Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adopted approach B.1 lineage B.1.621 BNT161b2 booster dose Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine development Evidence exacerbated Genetic genomic Genomic surveillance global mass vaccination Health implementation infections Intervention Lineage mass vaccination Mu variant mutations Neutralizing non-pharmaceutical interventions (NPIs) NPIs potential risk public health measure public health measures Recombination reported required respiratory restrict SARS-CoV-2 SARS-CoV-2 B.1.621 SARS-CoV-2 virus sera shown Strains Strategy sub-lineage B.1.621.1 Surveillance survivor the SARS-CoV-2 virus therapeutic threat vaccination Vaccine vaccine breakthrough. Vaccine development variant variants [DOI] 10.1080/21645515.2022.2027197 PMC 바로가기 [Article Type] Article
COVID-19: imbalanced cell-mediated immune response drives to immunopathologyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathogenesis. pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection [DOI] 10.1080/22221751.2022.2122579 PMC 바로가기
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations meta-analysis Meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
The Possible Impact of Nationwide Vaccination on Outcomes of the COVID-19 Epidemic in North Korea: A Modelling StudyArticle Published on 2022-10-242022-11-16 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis Asymptomatic B.1.1.529 calibrated compartmental model coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 transmission COVID-19 vaccination Democratic People's Republic of Korea dose Epidemic epidemiological epidemiological data Epidemiological models exacerbated Hospitalization Impact incidence indicated lack lifted measure National North Omicron variant outcome parameter Prevalence prevalence of COVID-19 projection proportion proportions public health reduced reported Risk assessment Spread suggested suppress suppressed the disease Transmissibility vaccination vaccination. Vaccine was used [DOI] 10.3346/jkms.2022.37.e300 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants variants. Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
SARS-CoV-2 Seroprevalence Study in Pediatric Patients and Health Care Workers Using Multiplex Antibody ImmunoassaysArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adults affected antibody Antigen Beta children circulating Clinical characteristics Cohort correlation COVID-19 delta variant disease ELISA estimate exacerbated False positive Gamma group HCW Health healthcare healthcare worker Healthcare workers highlight hospitals IgA IgA response IgG IgM indicated Infection isotype lowest Luminex assay Mild nucleocapsid PIMS-TS positive correlation RBD recruited SARS-CoV-2 SARS-CoV-2 proteins sensitivity Seropositivity seropositivity. Seroprevalence significantly lower Spain Spanish specificity study period the receptor-binding domain variants were measured worker [DOI] 10.3390/v14092039 PMC 바로가기
Cognitive Training via a Mobile Application to Reduce Obsessive-Compulsive-Related Distress and Cognitions During the COVID-19 Outbreaks: A Randomized Controlled Trial Using a Subclinical CohortRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: Behavior therapy [Category] 임상, [키워드] analysis application baseline Cognition Community Controlled COVID-19 COVID-19 pandemic disorder Effect evaluated exacerbated Follow-up GG OCD high risk impairment indicated initial screening Intervention mHealth Mobile OCD pandemic pandemic. participant psychiatric disorder Randomized Randomized controlled trial recent reduce reducing reduction Research Standard deviation Subclinical Symptom Symptoms training treat Treatment two groups [DOI] 10.1016/j.beth.2021.12.008 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of intensive weight-loss intervention on metabolic, ultrasound and anthropometric parameters among patients with obesity and non-alcoholic fatty liver disease: an RCTRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European journal of clinical nutrition [Category] 임상, [키워드] ALT AST attenuation baseline BMI Completer Contact Control control arm Controlled Effect effective Efficacy exacerbated Fatty liver groups hospital India Intensive Intervention intervention arm liver enzymes measurement NAFLD normalized obesity outcomes pandemic parameter parameters participant Patient patients with obesity Randomized RCT significant decrease significantly significantly higher steatosis stiffness therapy treat analysis Treatment outcome Trial was done weight were measured [DOI] 10.1038/s41430-022-01111-8 PMC 바로가기 [Article Type] Randomized Controlled Trial